Estimation of Additive, Dominance, and Imprinting Genetic Variance Using Genomic Data

Estimation of Additive, Dominance, and Imprinting Genetic Variance Using Genomic Data

Traditionally, exploration of genetic variance in humans, plants, and livestock species has been limited mostly to the use of additive effects estimated using pedigree data. However, with the development of dense panels of single-nucleotide polymorphisms (SNPs), the exploration of genetic variation of complex traits is moving from quantifying the resemblance between family members to the dissec...

Mixed Model Methods for Genomic Prediction and Variance Component Estimation of Additive and Dominance Effects Using SNP Markers

We established a genomic model of quantitative trait with genomic additive and dominance relationships that parallels the traditional quantitative genetics model, which partitions a genotypic value as breeding value plus dominance deviation and calculates additive and dominance relationships using pedigree information. Based on this genomic model, two sets of computationally complementary but m...

Additive Genetic Variance

Estimation of additive genetic variance when base populations are selected.

A population of size 40 was simulated 1,000 times for 10 generations. Five out of twenty males were selected each generation, and each male was mated to four females to have two progeny. The additive genetic variance (sigma 2a) before selection was 10, and the initial heritability was .5. Due to covariances among animals, inbreeding and gametic disequilibrium, the genetic variance was reduced t...

Detection of Genetic Differences between Holstein and Iranian North-West Indigenous Hybrid Cattles using Genomic Data

Extended Abstract Introduction and Objective: Selection to increase the frequency of new mutations useful only in some subpopulations leaves markers at the genome level. Most of these regions are related to genes and QTLs controlling significant economic traits. Material and Methods: In order to detection of genetic differences between Iranian northwestern crossbred and Holstein cattle breed,...